Pipeline

Our Therapeutic Pipeline

Our robust pipeline includes several promising candidates at various stages of development, from discovery to clinical trials.

Product Pipeline

AbBC’s therapeutic pipeline is built on a proprietary Granzyme B–Fc fusion platform that delivers a consistent and well-defined mechanism of action across all targets. While each candidate is directed against a distinct disease-associated surface antigen, all programs leverage the same Granzyme B–mediated intracellular apoptotic pathway. This platform architecture enables rapid generation of new candidates with shared pharmacologic principles, reducing development risk while efficiently expanding portfolio breadth across multiple oncology indications.

MoleculeIndicationDiscoveryIND EnablingPhase 1
GrB-Fc-IT4 (Targets Fn14)Oncology: Breast, Colorectal, Lung, Ovarian, Prostate, Pancreatic, Melanoma, Liver, Glioblastoma, Glioma
GrB-Fc-VEGF (Targets KDR/VEGFR2)Oncology: Broad Cancer, Ophthalmology: Wet AMD & Choroidal Neovascularization
GrB-Fc-SD1 (Targets Mesothelin)Pancreatic Ovarian
GrB-Fc-4D5 (Targets Her2/Neu)Breast, Gallbladder, Bladder, Esophageal/Gastric Junction, Stomach
GrB-Fc-Anti-Fra (Folate Receptor A)Gastrointestinal, Gynecological, Breast, Lung, Head & Neck, Leukemias, Lymphomas
GrB-Fc-CEA (Targets CEA)Colon/Colorectal/Esophageal/Gastric, Breast, Prostate, Lung, Thyroid, Pancreatic, Ovarian
GrB-Fc-HMEL (Targets SCPG4)Melanoma, Lobular Breast, TNBC, Breast Stem Cells, Gliomas, and Squamous Cell Carcinomas

MEET THE
TEAM
EXPERTS

A multidisciplinary team of scientists, clinicians, and drug development leaders with deep expertise in oncology, biologics, translational R&D, and GMP manufacturing, united by one goal: redefining targeted immunotherapy.